Ribosomal RNA (rRNA) targeting is easy to perform and offers the high sensitivity of nucleic acid tests. Roka’s license of Gen-Probe’s (now Hologic’s) patented rRNA targeting technology provides in-solution reactions that result in nucleic acid probe assays with higher sensitivity due to the increased cellular copy levels of rRNA versus DNA.
Why is RNA Better?
There can be up to 10,000 copies of the rRNA versus 1 copy of the DNA of a targeted molecule. This extra sensitivity comes from the unique ability to “dial in” on the desired detection sequences for its assays.
rRNA Targeting Advantages:
Reduced risk of false negatives
More flexibility in target design
Comprehensive inclusivity while maintaining strict exclusivity